باقر افتخاری سیس

Herein, a novel pH and thermosensitive polymer was synthesized through the polymerization of allyl alcohol, N-vinylcaprolactam, and sodium alginate from the tungsten disulfide surface as the nanocarrier. The attachment of polymer on the tungsten disulfide surface was characterized using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, X-ray diffraction, dynamic light scattering, and thermogravimetric analysis. To achieve optimum parameters, several parameters, including pH, contact time, vortex time, and temperature were studied. Drug delivery experiments of the obtained nanocarrier were studied using flutamide as a model anticancer drug. To investigate the efficiency of nanocarrier for controlled release of flutamide, in vitro drug delivery experiments were performed in simulated human (pH = 7.4) and cancer (pH = 5.6) conditions at different temperatures. Also, the near-infrared triggered effective and controllable release of flutamide from nanocarrier under near laser radiation (808 nm) is successfully studied. The adsorption mechanism could be well defined with Langmuir isotherm and the pseudo-second-order kinetic models. In the in vitro, flutamide delivery investigation indicated that the drug was released at pH = 5.6 at 45 °C with a release percentage of 99.54%. In comparison it was released at pH = 5.6 at 37 °C with a release percentage of 83.37%. The drug release amount under near-infrared laser irradiation reached 95.25% over 15 min. The drug release from nanocarrier was modeled, and based on R2 values, the Korsmeyer-Peppas model was introduced as the best model for predicting the release behavior. The cytotoxicity effects of the samples against PC-3 prostate cancer and HPrEC prostate normal cells through MTT assay were studied. The MTT test shown that nanocarrier significantly kills prostate cancer cells. Thus, the obtained data in this study shows that the nanocarrier is a promising drug carrier for controlled the relea