Abastract: Initially, nickel hydroxide nano-plates were synthesized using a straightforward hydrothermal method with the presence of Arginine amino acid acting as a shape-directing and pH-adjusting agent [1]. The characteristics of these nano-plates were analyzed through techniques such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray (EDX), and infrared spectroscopy (IR). Results indicated that the nano-plates exhibited a confetti-like morphology with an average thickness of 34 nm and high purity [2]. Subsequently, these nickel hydroxide nano-plates were utilized as a modifier in a carbon paste electrode. Cyclic voltammetry studies performed at different scan rates revealed a linear correlation between anodic and cathodic peak currents and the square root of the scan rates, indicating a diffusion-controlled process. Key kinetic parameters such as electron transfer coefficient and kinetic electron transfer rate constants were determined using the laviron equation. By employing Chronoamperometry and the Cottrell equation, the diffusion coefficient for Pramipexole was computed as 1.42×10-6 cm2 s-1. Finally, an amperometric methods were developed for measurement of Pramipexole drug on modified carbon paste electrode. Dynamic linear range, detection limit, relative standard deviation (for n=6 at a level of 10 μM) and sensitivity achieved for Pramipexole drug were 1-75 μM, 0.15 μM, 3.7% and 0.045 μA μM-1 respectively. To assess selectivity, the impact of interfering chemicals was also explored. These methodologies were subsequently employed for the determination of Pramipexole in blood serum samples.
