Introduction: Polyoxometalates (POMs) are a group of inorganic complexes of early transition metals and
oxygen atoms. These compounds have has been suggested to have some important medical applications
including antiviral, antibacterial, antitumor and antidiabetic activities. Diversity of structure of the
compounds that belong to the group of the materials is continuously widening with the introduction of new
POMs in the scientific literature. Before one can ascribe any medical application to a newly synthesized
chemical compound, toxicity studies of the material should be conducted in living systems. Therefore, the
purpose of the present study was to evaluate acute toxicity of a newly synthesized polyoxomolibdate:
(NH4)12[Mo36 (NO) 4 O108 (H2O) 16].
Methods: Acute toxicity study was conducted according to OECD protocol no.420 using the fixed-dose
method. Before starting the test a sighting study showed that starting dose was 50 mg/kg. Male rats were
grouped into four groups (n=5). One group received intraperitoneal saline and the other three groups
received polyoxomolibdate doses of 5 and 50 mg/kg. Then, the signs of morbidity and mortality were
monitored for 14 consecutive days.
Results: None of the animals that received the doses of 5 and 50 mg/kg died before day 14 of the
experiment. The animals that received the dose of 300 mg/kg showed great suffering, and the animals
sacrificed immediately after the appearance of the signs. Histopathological evaluation of the liver of the
animals showed some pathological changes like focal necrosis in the liver tissue and extravasation in the
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central veins of liver lobules. These changes were more severe in those animals that received the higher
dose of the substance. Kidney analysis showed some pathologic damages like kidney fibrosis.
Conclusion: Acute toxicity study demonstrated that this newly synthesized polyoxomolibdate,
(N