A bstract Introduction: Burn is among the traumas that impose great physical and psychological da mages to the injured people . Scientists still are looking for new treatments and methods for burn management that lack the defects of previous ones. Recently, the potential of probiotic bacteria for the treatment of skin disease and problems has been inves tigated . Considering that the effects of probiotics are strain - dependent, the aim of current study was to evaluate the effects of Lactobacillus rhamnosus (ATCC 7469) on the process of burn wound healing. Materials and methods : After induction of second - deg ree burn wounds on the back of rats, they were randomly divided into experimental, vehicle control , and negative control groups. The experimental groups received a bacterial ointment for 1, 3, 7 , and 14 days. The vehicle control groups received Eucerin for durations like the experimental groups. The negative control groups received no treatment in the same days. The evaluation of wound healing was conducted macroscopically by computing of the healing percent and microscopically by Hematoxylin and Eosin stain ing of the tissue samples of the wound area on different days. Results: The wound healing percent in the experimental group, compared with control groups, significantly increased, until the day 7 of the experiments. Moreover, the microscopic results indica te that the bacteria may have some anti - inflammatory effects. Also, the bacteria increased the rate of fibroblastic migration and re - epithelialization in the wound area. Conclusion: Overall, L. rhamnosus (ATCC 7469) when used topically on the burn wounds may have some positive effects on the process of burn wound healing.
