This study was conducted to design a model of nurses' vulnerability to stress based on attachment to God, positive and negative perfectionism and personal intelligence. The sample of the study was 250 nurses of hospitals located in West Azerbaijan province who were selected using availability sampling. The data were collected through Miller and Smith's Stress Vulnerability Questionnaire (Miller & Smith 1985), Mayer's Personal Intelligence Questionnaire (2013), Beck and McDonald's Attachment Scale (2004) and TriShort et al.'s Perfectionism Questionnaire (1995). The structural equations and data analysis were performed using SPSS and Amos software using descriptive and inferential tests including Pearson correlation coefficient, Bootstrap and Sobel. The results showed that the following variables i.e. positive perfectionism, negative perfectionism and attachment to God interact with the mediating role of personal intelligence in explaining nurses' vulnerability to stress, which in total 35% of the variance of nurses' vulnerability to stress is explained through these variables. The direct effect of attachment to God (-0.36), personal intelligence (-0.48), positive perfectionism (-0.31) and negative perfectionism (0.38) on estimating nurses' vulnerability to stress was significant. Indirect effect of attachment to God (t-value = 2.53), positive perfectionism (t-value = 2.41) and positive perfectionism (t-value = 1.98) mediated by significant personal intelligence was observed.