Salinity is a worldwide stressor that influences the growth and productivity of plants. Some novel
compounds like; graphene oxide and nutrients such as Se and Fe especially as nano form may improve
plant responses to the environmental stress factors. The soil‑based graphene oxide (0, 50, and 100
g kg−1 ) and the foliar applications of Se and nano‑Fe (control and 3 mg L −1 ) were assayed on grapevine
cv. Sultana under salinity (0, 50, and 100 mM NaCl). The top flavonoids, chlorophyll b, and plant dry
weight belonged to graphene oxide and nano‑Fe applications. CAT activity was improved in response
to Se, nano‑Fe, and graphene oxide (50 g kg −1 ). The least Fe, K, Se, N, Mg, Mn, and Zn content was
recorded for 100 mM NaCl. In contrast, the higher data for K, Se, Ca, Mg, Zn and Mn were acquired
with graphene oxide × foliar treatments. In general, graphene oxide treatment (50 g kg −1 ) × nano‑Fe
and Se foliar use ameliorated the adverse salinity effects with the improved biochemical and
physiological responses of Sultana grape.