Cu2+ ions immobilized on a novel magnetic chitosan-based catalytic system were prepared in combination with laponite RD. The CuII–magnetic chitosan/laponite RD (Cu–mCSLap) nanocomposite was characterized via X-ray diffraction, energy dispersive X-ray, scanning electron microscopy, and transmission electron microscopy. Further, the catalytic activity of this well-defined material was investigated in three-component CuAAC reactions to obtain 1,4-disubstituted-1,2,3-triazoles in good to excellent yields from an organic halide, sodium azide, and an alkyne using air-in-water as a green solvent.
