The experiment was planned to determine the most effective leaf-applied plant growth regulators (PGRs) for the optimum performance of chickpea (Cicer arietinum L.) cultivars and to select the most promising cultivar. The PGRs viz., indole-3- acetic acid, gibberellic acid, kinetin, salicylic acid and triacontanol and the cultivars, DCP 92-3, GNG-469, KWR-108 and local (H1). Biochemical characteristics like carbonic anhydrase activity (CA), nitrate reductase (NR) activity, yield parameters viz., number of pods per plant, seed number per pod, 100-seed weight, seed yield per plant, and quality attributes i.e., seed protein content were affected by all foliar PGRs but most promising with GA. On one hand, among the cultivars, DCP 92- 3 gave the maximum seed yield which was 60% higher over local. Similarly, on other hand, among the PGRs, GA produces the 175% higher seed yield than water-sprayed control (Fw). The interaction treatment was found non-significant for most of the parameter mentioned above.