Potato production needs precise management of soil fertility and water supplies. This study was carried out to determine the effects of different fertilizers on potato cultivar. The experiment was designed as a randomized complete block design with three replications and three treatments consisted on NanoCa; nano-chelated calcium (2 kg ha-1), NanoZn+B; nano-chelated zinc and boron (1 kg ha-1) and Nano- Com: nano-chelated complete fertilizer (1 kg ha-1). Plant height (PH), number of stems main (NS), stem diameter (MSD), number of the days to row closure (DRC), number of days to maturity (NDM), harvest index (HI), mean tuber weight (MTW), Mean tuber diameter (MTD), tuber weight per plant (TWP), tuber yield (TY), dry matter content (DM) nitrate content (NC), and starch content of initial fresh (ST) were measured. Analysis of variance showed that the effects of nano-fertilizers on all measured traits were statistically significant. The tallest plants were recorded when using NanoCa and NanoZn+B, while the lowest plants were observed in Nano- Com. The response of TY was similar to TWP and the highest tuber yield was produced via application of NanoCa and NanoZn+B nano-fertilizers. NanoZn+B and Nano-Com nano-fertilizers caused high performances in DM, but simultaneously produced high NC as a harmful component. Considering all traits, it seems that application of NanoCa nano-fertilizer is more useful for achieving high amounts of most important traits of potato flowed by NanoZn+B nano-fertilizer. However, the performance and influence of Nano-Com nano-fertilizer. The results of the present experiment revealed that balanced crop nutrition through effective nano-fertilizers can improve potato crop yield.