One of the most active research areas in nanoscience, nanotechnology and advanced materials is the synthesis of functional magnetic nanoparticles (MNPs) which can easily be separated and recycled from the reaction solutions by an external magnet [1, 2]. we have synthesized CuFe2O4 magnetic nanoparticles and demonstrated that these magnetic nanoparticles are excellent catalyst for the azide–alkyne cycloaddition reactions. Because of the magnetic properties of the prepared CuFe2O4 nanoparticles, it could be easily recovered by means of an external magnetic field and reused upto three cycles in reaction with no significant loss in catalytic activity. According to catalyst leaching investigation, the reaction process is heterogeneously done in the presence of CuFe2O4 nanoparticles.