2024 : 11 : 22

Mohsen Padervand

Academic rank: Associate Professor
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Education: PhD.
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Research

Title
Efficient conversion of bio-waste lignin into high-value fluorescent nitrogen-modified carbon quantum dots for live-cell imaging
Type
JournalPaper
Keywords
Keywords: Bio-waste lignin Microwave conversion Carbon quantum dot Surface modification Biological imaging
Year
2024
Journal INDUSTRIAL CROPS AND PRODUCTS
DOI
Researchers Haitao ren ، Abdelkader Labidia ، Ting Gao ، Mohsen Padervand ، xinxin lian ، Chuanyi Wang

Abstract

Sustainable and green natural lignin raw materials are considered as reliable precursors for large-scale production of carbon quantum dots (CQDs). However, extracting CQDs with ultra-low cytotoxicity and favorable fluorescence properties from lignin remains a challenge. Herein, the bio-waste lignin was converted into crude CQDs by an eco-friendly and rapid microwave pyrolysis approach in just 15 min. The as-obtained CQDs modified with nitrogen-atoms (N-CQDs) display a representative graphite-like structure, strong hydrophilicity, tiny particle size of 6.9 nm, and bright green fluorescence with a quantum yield of approximately 22.2% and fluorescence lifetime of 4.29 ns. Moreover, the N-CQDs exhibit high fluorescence stability under the conditions of a range of pH (5–11), continuous UV irradiation (~2 h), and NaCl presence with concentrations of 0–1.2 mol/L. More importantly, the N-CQDs show negligible cytotoxicity. Even at the higher N-CQD concentration (300 μg/ mL), A549 cells still maintain over 90% activity. The N-CQDs could be utilized for fluorescence imaging in living cells based on the above favorable characteristics. The present work paves the way for the value-added utilization of bio-waste lignin and the production of safe cell imaging agents.