A simple microwave distillation was used in order to prevent the traditional prolonged hydrodistillation. To this end, the volatile compounds in aerial sections of Salvia hydrangea DC were analyzed. Then, headspace single drop micro-extraction (HS–SDME) was done that was connected to gas chromatography–mass spectrometry (GC–MS). Following irradiation, the volatile components of headspace were gathered through an n-heptadecane single drop. The relative peak areas, which were used as the index, optimized the conditions of extraction. The indexes of retention and mass spectra were used for confirmation of chemical configuration in the extracts of HS–SDME.
