2024 : 11 : 22
Mohammad Reza Akbarpour

Mohammad Reza Akbarpour

Academic rank: Professor
ORCID:
Education: PhD.
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Faculty: 1
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Research

Title
Antibacterial Ti–Cu implants: A critical review on mechanisms of action
Type
JournalPaper
Keywords
Antibacterial mechanisms,Ti–Cu implants,Contact killing,Ion releasing,Anti-infection Biomaterials, Antimicrobial
Year
2022
Journal Materials Today Bio
DOI
Researchers pezhman mahmoudi ، Mohammad Reza Akbarpour ، ، Fengjuan Jing ، Mohammad Reza hadidi ، behnam akhavan

Abstract

Titanium (Ti) has been widely used for manufacturing of bone implants because of its mechanical properties, biological compatibility, and favorable corrosion resistance in biological environments. However, Ti implants are prone to infection (peri-implantitis) by bacteria which in extreme cases necessitate painful and costly revision surgeries. An emerging, viable solution for this problem is to use copper (Cu) as an antibacterial agent in the alloying system of Ti. The addition of copper provides excellent antibacterial activities, but the underpinning mechanisms are still obscure. This review sheds light on such mechanisms and reviews how incorporation of Cu can render Ti–Cu implants with antibacterial activity. The review first discusses the fundamentals of interactions between bacteria and implanted surfaces followed by an overview of the most common engineering strategies utilized to endow an implant with antibacterial activity. The underlying mechanisms for antibacterial activity of Ti–Cu implants are then discussed in detail. Special attention is paid to contact killing mechanisms because the misinterpretation of this mechanism is the root of discrepancies in the literature.