In this manuscript, we study the hypercyclicity of weighted composition operators defined on the set of holomorphic complex functions on a connected Stein n-manifold M. We show that a weighted composition operator C_{ψ,ω} (associated to a holomorphic self-map ψ and a holomorphic function ω on M) is hypercyclic with respect to an increasing sequence (nl)_l of natural numbers if and only if at every p ∈ M we have ω(p) ̸= 0 and the self-map ψ is injective without any fixed points in M, ψ(M) is a Runge domain and for every M-convex compact subset C ⊂ M there is a positive integer number k such that the sets C and ψ^[nk](C) are separable in M. Keywords: Holomorphic, composition operators, hypercyclic, convex.