The cosmological implications of New Tsallis holographic dark energy (NTHDE) in Rastall theory have been studied. Using the data set that includes DESI BAO (DR2), PantheonPlus SNe Ia, 𝐻(𝑧) measurements, and BBN and the MCMC analysis, the key cosmological and model-specific parameters are constrained. The result is compared with that of the ΛCDM model indicating that in addition to providing a viable dynamical dark energy framework, predictions for 𝐻(𝑧) are slightly more consistent with intermediate-redshift observations. Generally, the model remains compatible with current data and offers testable deviations from ΛCDM for upcoming surveys. It is also seen that when the energy density of quantum fields in vacuum, exposed by NTHDE, is combined with the Rastall correction term to the general relativity, a plausible candidate for dynamical dark energy is obtained that mimic the current value of the dark energy density parameter reported in the ΛCDM model. The latter cannot be repeated by NTHDE alone. Although NTHDE is not always classically stable, dynamical stability analysis reveals a stable de-Sitter fate for the Cosmos. The study also confirms previous theoretical and observational constraints on the Rastall parameter obtained by focusing on the thermodynamics, early universe, pulsars, and the early-type galaxies.
