Weirs are a commonly used system to adjust water surface level and to control the fow in canals and hydraulic structures. Labyrinth weirs are a type of weirs that can pass through a certain amount of fow which has a lower upstream water level than the linear weirs, by increasing the efective length. In the present study, the performance of multilayer perceptron (MLP) networks, radial basis function networks and support vector machines with diferent kernel functions were investigated in order to estimate the discharge coefcient (Cd) of labyrinth weirs with quarter-round crests. For this purpose, 454 laboratory data were used. The non-dimensional parameters of L/W, a, W/P, and Ht /P were considered as the input, and the nondimensional parameter of Cd was regarded as the output in the models. In comparison with the other models, the performance of the MLP model with RMSE, R, and DC of 0.019, 0.985, and 0.971, respectively, was more acceptable and closer to the experimental data. Also, the data density plot and the violin plot showed that the dispersion and distribution of the probability of the estimated data to the MLP model with the data obtained from the laboratory have a very close and similar adaptation