Background: Burn is one of health problems that humankind has been encountered with in he history. Now, Silver Sulfadiazine, as an antibacterial agent, is the drug that preferentially used for treatment of burn wounds. Previous investigations showed that the drug has no role n accelerating the process of wound healing and furthermore it may have some side effects. Therefore, the necessity of developing new drugs for burn wound healing is under consideration. For many years, probiotic bacteria have been used in health and industry as safe and beneficial agents. In previous studies, the benefits of some probiotic bacteria on skin health were shown. Moreover, some studies on wound healing process indicates that some strains of probiotic bacteria may accelerate the process of wound healing either in burn wounds or other kinds of wounds. Considering that the effects of probiotics are strain-dependent, in the present study the effects of Lactobacillus rhamnosus on the process of wound healing in second degree burn wounds evaluated n male rats. Material and Methods: In the present study 60 male Wistar rat were used. The rats randomly divided in 12 equal groups. Induction of second degree burn wounds were conducted by a hot aluminum bar in the back of rats. Four groups of rats received no treatment as negative control groups. Four groups received vehicle ,eucerin, as positive control groups and four groups received probiotic bacteria in eucerin. The process of wound healing was assessed by measuring the wound areas and tissue sampling in days of 1,3,7,14 after induction of injury. Results: The area of wounds were significantly smaller in experimental group than the control ones in days of 3 and 7 after induction of wounds (P<0.05). Tissue section of wound area showed that the probiotic bacteria may reduce the period of inflammation of wound healing process. Conclusion: The results of present study is favorable to previous researches as in those researches some strain of pro
