BACKGROUND AND OBJECTIVES: In spite of reports on successfully treatment of infections using personalized bacteriophage therapy (BT), non personalized Bt didn't show expected results in studies. MATERIALS AND METHODS: In this review, the cases of successful Bt on difficult-to-treat infections and their outcomes were expressed. The infections were related to lower respiratory tract, skin and soft tissue and bone infection. RESULTS AND DISCUSSION: Eradication of infected bacteria and also clinical improvement of infections in 70% of cases were revealed clearly. Bacteriophage-antibiotic synergy was significant in the treatment. Low rate of adverse effects was observed. Based on findings, Bt in combination with antibiotic can be very effective in designing clinical trials.
