رضا معصومی جهاندیزی

Background: Breast cancer is the most frequent malignancy among women with a peak in 40–50 years in Asia. Despite the high frequency of breast cancer among Iranian women, the epidemiological characteristics of breast cancer among Iranian patients are yet unknown. The aim of this study was to analyze clinicopathologic characteristics to identify prognostic factors for women with HER2-positive breast cancer in Kermanshah. Materials and Methods: Between of 1393 to 1396, 70 patients with breast cancer, who were referred to oncologist laboratories, Kermanshah, Iran were studied. They were surveyed for age, size of tumor, family history of disease, laterality, type of pathology, grade, stage, tumor markers and metastasis. Results: The mean age of patients at diagnosis was 47.11±12.39 years old. Size of tumor in 14 patients (20%) was 0.1-2 cm, 46 patients (66.6%) between 2.1-5 cm and 9 patients (13.4%)>5 cm. four patients (5.7%) had grade I. 37 patients (52.9%) and 27 patients (41.4%) had, grade II and grade III, respectively. 30 patients (42.85%) had metastasis to other organs. 6 patients (8.57%) have family history of any cancer. Conclusions: The mean age at diagnosis of breast cancer in Kermanshah is around 45 to 50 years old. Significant clinical characters were observed in the Kermanshah patients with HER2-positive breast cancer. Furthermore, targeted anti-HER2 therapy may improve the prognosis of these patients.