Abstract In the present era, with the development of advanced tools such as molecular technique and bioinformatics software, a new way has been developed in the study of the human genome and other primates, as well as their genome comparison, which can be the beginning of the golden era for the molecular genetic study. Despite the fact that there are more than 90% of the similarities between the human genome and large monkeys, several millions of structural and single nucleotide differences are also visible between them. It seems that these differences are due to the evolution of a new phenotype. In this study, using bioinformatics data base and software, nine genes including; SOX9, FOXP2, DUF1220, APOC1, SIGLEC13, CLLU1, AQP7, PDYN and HAR1 in human and chimpanzee compared. The results show that these genes in two species despite significant similarities, but have seen nucleotide changes such as deletion, duplication, increase in length, and changes in the number of copies of the genes in them, which is likely to be in the direction natural selection have been made for human reconciliation.
