Introduction: Diabetes is a metabolic disorder whose pathologyalso involves systemic inflammation,which is pathogenic in associationwith immune cell cells, activation of inflammatorypathways, and the productionof certain inflammatory cytokines. Interleukin-6 (IL-6) is an inflammatory cytokine produced by immune cells andits levels in the body are associated with insulin sensitivity and glucose tolerance. Therefore, inhibition of IL-6 activity and signaling can be effective in preventing inflammatory diseases, especially type 2 diabetes, and improving the symptoms of these diseases. The aim of this study was to evaluate the simultaneous effect of aerobic training on IL-6serum levels in women with type 2 diabetes. Method: This study was a quasi-experimental study with a pre-test-post-test design and a control group, in which 24 women with type 2 diabetes were randomly assigned to 2 equal groups of training, and control. The subjects practiced for six weeks and every week for three days for 40- 60 min and at a heart rate of 45-65. Data analysis was performed using analysis of covariance and correlated t-test at the significant level of <0.05 Results: The results showed that after the intervention, IL-6 serum levels in the aerobic training group (P=0.01) had a significant decrease compared to the control groups. Conclusion: Based on the findings of the present study, it seems that aerobic training can reduce the levels of IL-6 a and protective effects in women with type 2 diabetes.
