Background & Aims: The pre-inflammatory cytokines responsible for TNF-α, CRP, and lipid profiles have an important role in the development and prevention of systemic inflammation and also the development of obesity-related diseases, including cardiovascular diseases. The purpose of this study was to investigate the effect of 12 weeks of Aqua training and green tea supplement on serum TNF- α, CRP, and cardiovascular risk factors in inactive obese women. Materials & Methods: In this quasi-experimental study, 60 women with body mass index of over 30 kg / m 2 were randomly assigned into 4 groups: control group, Aqua training group, green tea group, and Aqua training + Green tea group. The 12-week training program consisted of three 60-minute sessions per week with an intensity of 65-75% heart rate. Green tea supplements were also taken at 500 mg per day and in three equal portions. Blood samples were used for pre-test and post-test for TNF-α, CRP, and lipid profiles. Data were analyzed using SPSS software and the level of significance was set at 5%. Results: The data showed that in the combination group (Aqua training + green tea) (p< 0.05), green tea group (p<0.05), and Aqua training (p <0.05) there was a significant decrease in TNF and CRP in comparison with the control group. And the results of ANOVA test showed that there is a significant difference between the effects of different interventions on alpha TNF-α (p< 0.05). The results of Tukey's post hoc test for TNF-α and CRP showed that there was a significant difference between the control group and the combined group (Aqua training + green tea) (p <0.05), between the green tea group and the exercise group (p <0.05), and between the exercise group and the combination (Aqua training + green tea) (p <0.05). In addition, in the case of lipid profile changes following different interventions, there were significant differences between the three Aqua training, the green tea group and the combined group (Aqua training +
