ntroduction: obesity and overweight as a chronic and inflammatory metabolic disease has become one of the main health challenges all over the world and tumor necrosis factor alpha (TNF-α) as one of the pro- It is an inflammation that can play a role in the inflammation process and its increased level is associated with the inflammatory state in overweight people. In recent years, attention has been paid to the use of physical exercises and curcumin due to its strong antioxidant and anti-inflammatory properties. Therefore, the aim of this research was to investigate the effect of 12 weeks of endurence exercises along with curcumin consumption on α-TNF levels in inactive obese women. Method: The current semi-experimental research was conducted on 20 overweight women who were randomly divided into two supplement + exercise groups (10 people) and exercise group (10 people). The exercise+supplement group performed 3 sessions of interval training every week for 12 weeks with an intensity of 65-75% of the reserve heart rate and daily 20 mg per kilogram of body weight of curcumin supplement (Sina capsules) curcumin) and the exercise group only performed physical exercises. Blood sampling was done 24 hours before and after the start of training. The statistical method of one-way analysis of variance and paired t-test was used for data analysis. Results: Significant changes in the level of TNF-α were observed in the two exercise + supplement groups and the exercise group, respectively, p=0.002 and p=0.007 compared to the pre-test. Also, when examining the inter-group changes, the changes in TNF-α (p=0.003) of the exercise+supplement group were statistically significant compared to the exercise group. Conclusion: performing 12 weeks of intermittent exercises with moderate intensity along with curcumin caused a significant decrease in TNF-α. Keywords: interval training, curcumin, TNF-α, inactive obese wome
