Introduction: Obesity and high levels of inflammatory markers are associated with increased risk of chronic diseases such as type 2 diabetes and cardiovascular diseases. The aim of this study was to investigate the effect of TRX exercises on eotaxin and IL-33 indices in inactive obese women. Method: The current research was applied and semi-experimental. The statistical population of the present study was all obese women with an average age of 52 ± 2.6 years and BMI ≥ 25 in Maragheh city. From this population, 30 people were selected as a statistical sample in a purposeful and accessible manner and were randomly divided into two experimental (15 people) and control (15 people) groups. The exercise group was exposed to an 8-week TRX training program consisting of 10 minutes of warm-up, 40 minutes of TRX training, and 10 minutes of cool-down. Blood samples were collected before and after 8 weeks of training and the amounts of eotaxin and IL-33 were measured by ELISA method. The data were analyzed using the covariance test (P ≤ 0.05). Results: The results showed that 8 weeks of TRX training leads to a significant decrease in serum eotaxin levels (p=0.021) and a significant increase in IL-33 serum levels (p=0.011) in inactive obese women. Conclusion: It seems that the weight loss due to TRX exercises, which was accompanied by the loss of fat tissue, led to a decrease in eotaxin levels and an increase in IL-33 serum levels.
