Introduction: Lack of sufficient physical activity and obesity have caused chronic metabolic diseases including type 2 diabetes worldwide. While exercise training has positive effects on patients with type 2 diabetes. Therefore, the aim of this study was to investigate the effect of functional training on serum spexin levels in women with type 2 diabetes. Method: 20 women with type 2 diabetes voluntarily participated in the study and were randomly assigned to two exercise and control groups. Subjects in the exercise group performed selected exercise training for 12 weeks and three sessions per week. Serum fasting blood glucose, HbA1C, insulin resistance index, and serum spexin levels were measured. Data were analyzed using analysis of variance. Results: The results of the analysis of variance test showed that there was a significant difference between the effects of different interventions on serum spexin levels, blood glucose levels, and HbA1C and insulin resistance. Functional training led to an increase in serum spexin levels in the training group (p<0.05). Conclusion: It seems that the functional training intervention method is an effective method in controlling blood sugar and reducing inflammation and is recommended as an effective method for glycemic control in patients with type 2 diabetes.
