Veterans with post-traumatic stress disorder have low life satisfaction and this exacerbates their symptoms. Life satisfaction is the result of each person's cognitive assessment of life based on their own unique criteria and circumstances. Therefore, the present study was conducted to predict the life satisfaction of veterans with post-traumatic stress disorder based on cognitive flexibility and Alexithymia. In this descriptive-correlational study, 120 veterans with post-traumatic stress disorder who were hospitalized and treated in Isar Psychiatric Hospital in Ardabil in 2019 were selected as the available sample and examined. Data collection tools were Diner et al.'s Life Satisfaction Questionnaire, Dennis and Vander wall Cognitive Flexibility Questionnaire, and Toronto Emotional Dysfunction Questionnaire. Data were analyzed using Pearson correlation test and multiple regression analysis using SPSS 23 statistical software. Life satisfaction of veterans with post-traumatic stress disorder had a positive and significant relationship with cognitive flexibility and a negative and significant relationship with Alexithymia (p <0.05). Also, cognitive flexibility and Alexithymia of 68% of the variance scores predicted the level of life satisfaction of veterans with post-traumatic stress disorder (p <0.001). High cognitive flexibility and low Alexithymia improve life satisfaction in veterans with post-traumatic stress disorder. Therefore, training veterans to empower them in these areas is recommended.