The corona pandemic is a health issue, and the resulting home quarantine, family, and relationships between families have been affected. This study aims to determine the relationship between mothers'_ awareness and self-efficacy with mother-child interaction during quarantine caused by Coronavirus. The research design was descriptive and correlational. The statistical population of the study included all mothers with children aged 6 to 12 years in Rasht in the February of 2021, from which 205 people were selected by the available sampling. They completed the (FMI-S), (PSAM), and the mother-Child Relationship Scale. Data were analyzed using SPSS-24, Pearson correlation coefficient, and stepwise regression. The results showed that there is a positive and significant relationship between parents' mindfulness and mother-child relationship, and the relationship between parents' self-efficacy and mother-child interaction is positive and significant. Finally, data showed that Parental awareness and self-efficacy play a significant role in explaining the mother-child relationship. The results have practical implications for psychologists and family counselors regarding the quarantine and pandemic conditions such as coronavirus _ by improving the level of mindfulness and self-efficacy of mothers, the quality of mother-child relationships can be improved
