2024 : 11 : 14
Zohreh Jahanafrooz

Zohreh Jahanafrooz

Academic rank: Assistant Professor
ORCID:
Education: PhD.
ScopusId:
HIndex:
Faculty: 1
Address:
Phone: 04137278001-523

Research

Title
Interaction of Noncoding RNAs with Hippo Signaling Pathway in Cancer Cells and Cancer Stem Cells
Type
JournalPaper
Keywords
non-coding RNAHippo pathwaycancer cellcancer stem cell
Year
2024
Journal Non-coding RNA Research
DOI
Researchers Saba Abedimanesh ، Reza Safaralizadeh ، Zohreh Jahanafrooz ، Souzan Najafi ، Mohammad Amini ، Shabnam Soltani Nazarloo ، Behzad Baradaran ، ، Ahad Mokhtarzadeh

Abstract

The Hippo signaling pathway has a regulatory function in the organogenesis process and cellular homeostasis, switching the cascade reactions of crucial kinases acts to turn off/on the Hippo pathway, altering the downstream gene expression and thereby regulating proliferation, apoptosis, or stemness. Disruption of this pathway can lead to the occurrence of various disorders and different types of cancer. Recent findings highlight the importance of ncRNAs, such as microRNA, circular RNA, and lncRNAs, in modulating the Hippo pathway. Defects in ncRNAs can disrupt Hippo pathway balance, increasing tumor cells, tumorigenesis, and chemotherapeutic resistance. This review summarizes ncRNAs' inhibitory or stimulatory role in - Hippo pathway regulation in cancer and stem cells. Identifying the relation between ncRNAs and the components of this pathway could pave the way for developing new biomarkers in the treatment and diagnosis of cancers.