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Title
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New Page to Access Pyrazines and their Ring Fused Analogues: Synthesis from N-Propargylamines
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Type
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JournalPaper
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Keywords
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Pyrazines, ring fused pyrazines, N-propargylamines, 6-exo-dig cyclization, 1,3-dipolar cycloaddition
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Abstract
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The development of efficient routes to pyrazines and their ring fused analogues is an attractive area of research since these compounds are now widely recognized as important N-heterocycles for their potential use in medicinal and agricultural scientific fields. In this review, we describe the most representative and interesting methods for the synthesis of pyrazines from N-propargylamines. Mechanistic aspects of the reactions are consid- ered and discussed in detail.
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Researchers
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Mehdi D. Esrafili (Fifth Researcher), Ahmadreza Bekhradnia (Fourth Researcher), Ladan Edjlali (Third Researcher), Akram Hosseinian (Second Researcher), (First Researcher)
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