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Title
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Hydroxyapatite (HA)-based hybrid bionanocomposite hydrogels: Ciprofloxacin delivery, release kinetics and antibacterial activity
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Type
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JournalPaper
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Keywords
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Polyvinyl alcohol Physical cross-linking κ-carrageenan Drug delivery Release kinetics Antibacterial activity
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Abstract
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The current study developed a series of novel biomaterials based on the growth of calcium phosphate (HA) within the polyvinyl alcohol/κ-carrageenan (PVACar) hydrogels to assess their potential as drug delivery system. All synthesized samples were analyzed by using common techniques e.g. Fouriertransform infrared spectroscopy (FT-IR), transmission electronmicroscopy (TEM), scanningelectron microscopy(SEM)with an energy-dispersive X-ray (EDX) spectroscopy and X-ray diffraction (XRD). Ciprofloxacin (as a drug model) encapsulation efficiency and release performance of the samples were investigated. Experimental results showed that the incorporation of HA led to sustain release of ciprofloxacin, whereas about ~ 70% of ciprofloxacin was diffused from pristine PVACar sample during 30 h. The kinetic investigations showed the best fit with Korsmeyer-Peppas model with Fick's diffusion as the drug release mechanism.Moreover, the performance of ciprofloxacin-loaded hydrogels as antibacterial hydrogels was tested, which showed good antibacterial activity against Gram-positiveStaphylococcus aureus and Gram-negative Escherichia coli bacteria.
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Researchers
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Ali Akbari (Fifth Researcher), Maryam Hazrati (Fourth Researcher), Hessam Jafari (Third Researcher), Gholam Reza Mahdavinia (Second Researcher), Samira Alinavaz (First Researcher)
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