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Title
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Biosynthesis of AgNPs onto the urea-based periodic mesoporous organosilica (AgxNPs/Ur-PMO) for antibacterial and cell viability assay
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Type
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JournalPaper
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Keywords
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Cell viability assayAgNPsPeriodic mesoporous organosilica (PMO)Urea-based PMO (Ur-PMO)Antibacterial activity
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Abstract
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Nano-size silver particles were stabilized on the inner surfaces of urea based periodic mesoporous organosilica (Ur-PMO). Aqueous extract of Euphorbia leaves as a sustainable and green reducing agent was applied for Ag-nanoparticles growth into the Ur-PMO channels. Physical and chemical properties of organosilica materials synthesized using various techniques such as FT-IR, small-angle XRD, PXRD, FESEM, TEM, SEM-EDX and atomic absorption spectrometry (AAS) were examined. Finally, the AgNPs/Ur-PMO were investigated on cell viability assay. An in vitro cytotoxicity test using MMT assay displayed that the designed material has good biocompatibility and could be a promising candidate for biomedical applications. The results also showed that the AgNPs/Ur-PMO compounds (especially, PMO; 1.27% AgNPs) had relatively good antibacterial and antibiofilm effects. It seems that the use of these compounds in hospital environments can reduce nosocomial infections as well as reduce antibiotic-resistant bacteria.
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Researchers
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Rovshan Khalilov (Not In First Six Researchers), Samad Khaksar (Not In First Six Researchers), Ali Valizadeh (Not In First Six Researchers), Asghar Tanomand (Fifth Researcher), Aziz Eftekhari (Fourth Researcher), Sadegh Rostamnia (Third Researcher), Behnam Gholipour (Second Researcher), Amir Hasanzadeh (First Researcher)
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