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Title
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Evaluation of subacute toxicity of Lactobacillus rhamnosus (ATCC: 7469) with haematological and biochemical parameters in male Wistar rats
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Type
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Presentation
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Keywords
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Subacute toxicity, Wistar rat, serum parameter, haematological parameters.
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Abstract
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One of the main criteria of probiotics is their safety. The purpose of present research was to evaluate the safety of Lactobacillus rhamnosus (ATCC: 7469) in male Wistar rats. A subacute 28-day toxicity study was conducted. Two groups of male rats (n=6/group) were used. Control group received saline and the experimental group received 1 × 109 CFU/rat of L. rhamnosus (ATCC: 7469) for 28 consecutive days. Analysis of weigh changes, general observations, hematological factor, and serum parameters showed no toxicity of the bacterium in male Wistar rats.
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Researchers
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Babak Khalifeh Zadeh Kaleibar (Third Researcher), ََAmir Abbas Barzegari (Second Researcher), Seyed Ali Alavi (First Researcher)
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