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Title
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Evaluation of Silibinin Effect on U-CH2 and MCF-7 Cell Lines through xCELLigence system
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Type
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JournalPaper
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Keywords
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Silibinin; MCF-7; U-CH2; xCELLigence
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Abstract
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Silibinin is an herbal polyphenol with high antioxidant and anticancer properties. In this study, its influence on U-CH2 (human sacral chordoma cell line) and MCF-7 (human breast adenocarcinoma cell line) cells was investigated and compared. We analyzed real-time cell viability by xCELLigence system. It was found that the cytotoxic effect of silibinin began about 10 hours after administration. Silibinin differentially influenced MCF-7 and U-CH2 cells and caused decrease in the cell index value of MCF-7 cells more than U-CH2 cells (more than 2 times) at 24 h. This suggests that silibinin is a promising drug for breast cancer but less favorable for chordoma.
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Researchers
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Beate Rinner (Second Researcher), Zohreh Jahanafrooz (First Researcher)
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