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Title
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Catalytic and Antitubercular Activities of Multifunctional Copper(II)–Schiff Base Complexes: Insights into Structure, Theoretical Calculations, and Physicochemical Behavior
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Type
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JournalPaper
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Keywords
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Physicochemical
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Abstract
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Three copper(II) complexes featuring tridentate ONO donor Schiff base ligands were synthesized and thoroughly characterized by X-ray crystallography, spectroscopy, and electrochemical methods. Density functional theory (DFT) calculations provided insights into their electronic structures and ligand–metal interactions. Complex 1 exhibited moderate catalytic activity toward the selective oxidation of toluene and styrene under mild conditions. Biological assays demonstrated measurable antimycobacterial effects against drug-sensitive and -resistant Mycobacterium tuberculosis strains, while combination studies with standard anti-TB drugs revealed mainly additive or indifferent interactions. These results highlight the promise of these copper(II) Schiff-base complexes as multifunctional agents with catalytic and therapeutic applications.
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Researchers
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Ghodrat Mahmoudi (Not In First Six Researchers), Ewa Augustynowicz-Kopeć (Not In First Six Researchers), Agnieszka Głogowska (Not In First Six Researchers), Mateusz Janeta (Not In First Six Researchers), Patrycja Miller (Not In First Six Researchers), Maciej Hodorowicz (Fifth Researcher), Mateusz Brela (Fourth Researcher), Janusz Szklarzewicz (Third Researcher), Weronika Bogdał (Second Researcher), Anna Jurowska (First Researcher)
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