In this paper, we point out thermodynamical description of ghost dark energy (GDE) and its generalization to the early universe. Thereinafter, we find expressions for the entropy changes of these dark energy (DE) candidates. In addition, considering thermal fluctuations, thermodynamics of the DE component interacting with a dark matter (DM) sector is addressed. We will also find the effects of considering the coincidence problem on the mutual interaction between the dark sectors, and thus the equation of state parameter of DE. Finally, we derive a relation between the mutual interaction of the dark components of the universe, accelerated with the either GDE or its generalization, and the thermodynamic fluctuations.
