عنوان مجله
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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کلیدواژهها
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Magnetic hydrogel, k-Carrageenan, Chitosan, Complex, Methtrexate Release
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چکیده
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The aim of the present work was to develop green carriers for methotrexate using -carrageenan/chitosan
complexes. Magnetic Fe3O4 nanoparticles were first synthesized in the presence of -carrageenan
through in situ method. Then, the obtained magnetic -carrageenan was crosslinked using the polycation chitosan biopolymer. The physical and structural properties of hydrogels were investigated by
FTIR, XRD, SEM, TEM, TGA, and VSM techniques. The pH-dependent swelling behavior of hydrogels was
examined in various buffer solutions. All of the prepared hydrogels showed a high swelling capacity in
basic solutions. The introduction of magnetite nanoparticles into -carrageenan/chitosan complexes had
a significant effect on the swelling capacity of magnetic hydrogels, as the water absorbency of hydrogels
decreased with increasing magnetite content. Methotrexate as an anticancer and model drug was loaded
on hydrogels and the release profiles were investigated at pH = 7.4 and 5.3. The methotrexate encapsulation efficiency was increased by increasing magnetite and chitosan contents. The results demonstrated
that the release of methotrexate from magnetic hydrogels is pH-dependent with a high release content
at pH = 7.4. The release profiles were analyzed by Peppas’s empirical model and the release of drug from
hydrogels followed Fickian type of diffusion mechanism at both pHs.
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