چکیده
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Probiotics are microorganisms that when are administered
in enough quantities to their host have beneficial effects
for them. The use of oral administration of probiotics for
the treatment of some skin problems, especially the
wounds, have been shown in previous research. Because
the effects of probiotics depend on the strain that is used,
the purpose of the current study was to evaluate the effects
of Lactobacillus rhamnosus on the wound healing process.
For this, with a heated aluminum bar deep second- degree
burn wounds were induced on the back of 60 male Wistar
rats. The rats randomly assigned to experimental (received
bacteria in distilled water by gavage), negative control
(received no treatment) and vehicle control (received
distilled water by gavage). The period of the experiments
was 14 days. Measurement of wound healing percent and
microscopic evaluation of the wound area in the days 1, 3,
7 and 14 post-burn were conducted. The results showed
that the wound that received the probiotic bacteria had the
higher percent of wound healing compared to the control
alternatives in the days 7 (P<0.05) and 14 (P<0.01) of the
experiments. Moreover, in the wounds that received the
bacteria, inflammatory response was reduced but the rate
of fibroblastic migration, granulation tissue formation,
andreepithelializationwere increased. Overall,
Lactobacillus rhamnosus had positive effects on the deep
second-degree burn wound healing process.
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