کلیدواژهها
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Renal toxicity, Acetaminophen, Lactobacillus rhamnosus, Wistar rats, Probiotics
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چکیده
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Background and Aim : Today, the use of probiotics in the treatment and prevention of diseases
is increasing. It has been shown that different species of genus Lactobacillus, as probiotic bacteria,
might prevent some injuries induced by oxidative stress in laboratory animals. Oxidative stress has
an important role in acetaminophen-induced renal toxicity. Therefore, the present study aimed to
investigate the effects of Lactobacillus rhamnosus on acetaminophen-induced renal toxicity.
Methods : In this study, four groups of laboratory rats (6/group) were used. The negative control
group received no treatment. Acetaminophen control group received a single high dose of
acetaminophen (1000 mg/kg, orally). The bacterial control group received 6×109 CFU of the
bacterium (orally) daily for two weeks. The experimental group, after receiving 6×109 CFU of
Lactobacillus rhamnosus daily for two weeks, received a single high dose of acetaminophen (1000
mg/kg). One day after acetaminophen administration, sampling of blood serum and kidney tissues
was conducted for all groups.
Results : The amount of urea and creatinine in the acetaminophen control group was significantly
higher than the amount of these parameters in the negative control and bacterial control groups but
not the experimental group. Renal tissue analysis showed damages such as glomerular necrosis
and degeneration of tubular cells in both groups that received acetaminophen. Kidney tissue in the
negative control and bacterial control groups had a normal appearance.
Conclusion : : Lactobacillus rhamnosus has no preventive effects on renal toxicity caused by
acetaminophen in Wistar rats.
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