عنوان مجله
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Pharmaceutical and Biomedical Research
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چکیده
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Background: It is believed that the consumption of an adequate amount of live lactic acid
bacteria (as probiotic) may improve the health of the host. Many strains of lactic acid bacteria
are generally considered to be safe. However, some strains have shown some adverse effects.
Objectives: This study aimed to investigate the safety of a new strain of Lactobacillus
pentosus (IBRC=11143) in Wistar rats.
Methods: In this experimental study, male and female Wistar rats (n=6) were used. A subacute
toxicity study (for 28 days) was conducted by oral administration of Lactobacillus pentosus
to the animals. In each sex, one group received saline, and the other two groups received the
bacteria at doses of 1×108 and 1×109 Colony-Forming Units (CFU)/rat.
Results: No significant alteration in the liver and kidney tissues was seen. However, in both
sexes, there were significant differences in urea and creatinine levels between the control and
the experimental groups. Some blood parameters (Lymphocyte, red blood cell, hematocrit,
and hemoglobin) also showed significant changes in the groups that received the bacteria.
Moreover, a significant increase in alkaline phosphatase level was observed in male rats.
Conclusion: The results indicate that Lactobacillus pentosus (11143) is not entirely safe like
other Lactobacillus strains. Therefore, the Lactobacillus pentosus (11143) strain may not be
the right choice as a probiotic for human consumption
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