عنوان مجله
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Journal of Molecular Structure
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چکیده
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The present study aimed to develop an easy controlled release system for salicylic acid (SA) through
ionotropic gelation of chitosan (CTS) using tripolyphosphate (TPP) as cross-linker. The synthesized
nanoparticles (SA/CTS NPs) were characterized for their physicochemical properties by various techniques
including Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscopy (SEM) with an energy-dispersive X-ray (EDX) spectroscopy, X-ray photoelectron
spectroscopy (XPS) and X-ray diffraction (XRD). A maximum encapsulation efficiency (EE) of 84% was obtained. The obtained material not only was tested as drug delivery system in neutral (pH 7.4) and acidic
medium (pH 5.5) but also the kinetic release behavior of SA from the CTS NPs was investigated based
on two models namely Korsmeyer-Peppas and Higuchi. These data demonstrated that the drug release
mechanism governed by Korsmeyer-Peppas model. Finally, the cytotoxic effects of free SA and SA/CTS NPs
were evaluated in-vitro against breast cancer (MDA-MB-231) cell lines by MTT assay. Results showed that
SA/CTS NPs were more cytotoxic than free SA. This work suggested the potential of SA/CTS NPs system
as an effective anticancer system.
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