کلیدواژهها
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MicroRNA, IsomiR, Arm selection, DNA methylation, LncRNA, Xeno-infection
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چکیده
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MicroRNA-derived structures play impressive roles in various biological processes. So dysregulation of miRNAs can
lead to different human diseases. Recent studies have extended our comprehension of the control of miRNA function
and features. Here, we overview some remarkable miRNA properties that have potential implications for the
miRNA functions, including different variants of a miRNA called isomiRs, miRNA arm selection/arm switching, and the
effect of these factors on miRNA target selection. Besides, we review some aspects of miRNA interactions such as the
interaction between epigenetics and miRNA (different miRNAs and their related processing enzymes are epigenetically
regulated by multiple DNA methylation enzymes. moreover, DNA methylation could be controlled by diverse
mechanisms related to miRNAs), direct and indirect crosstalk between miRNA and lnc (Long Non-Coding) RNAs as a
further approach to conduct intercellular regulation called “competing endogenous RNA” (ceRNA) that is involved in
the pathogenesis of different diseases, and the interaction of miRNA activities and some Xeno-infectious (virus/bacteria/
parasite) factors, which result in modulation of the pathogenesis of infections. This review provides some related
studies to a better understanding of miRNA involvement mechanisms and overcoming the complexity of related
diseases that may be applicable and useful to prognostic, diagnostic, therapeutic purposes and personalized medicine
in the future.
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