چکیده
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Previous studies documented that Lactobacillus paracasei has obvious in vitro cholesterol-lowering
abilities. In this study, initially, L. paracasei was tested in terms of antibacterial properties as well
as antibiogram profile. Then, the safety of the mentioned strain was evaluated in rats. Evaluation
of antibiotic susceptibility revealed that the L. paracasei strain had high antibiotic resistance to
several antibiotics as well as a great ability to autoaggregation. After identification of the probiotic
aptitude, six groups of six rats from both sexes were used (three groups of each sex).
L. paracasei was administered to the experimental groups via drinking water for 28 days (1 × 108
and 1 × 109, respectively). The negative control group received only tap water during this period.
Hematological indicators, serum liver enzyme activity including (alanine transaminase (ALT),
alkaline phosphatase (ALP), and aspartate transaminase (AST)) as well as serum creatinine and
urea were evaluated at the end of 28 days. The blood and serum factors were not changed
significantly during the 28 days. The only noticeable difference was the increase of blood urea in
both sexes which was in a normal range. Furthermore, the evaluation of antagonistic properties
revealed that L. paracasei had antibacterial aptitude against Escherichia coli and Staphylococcus
aureus. In conclusion, this strain has good cholesterol-lowering and antibacterial properties and is
a safe supplement in Wistar rats.
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