چکیده
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The current study describes the in-situ growth of ZnS/MoS2
on cellulose
paper using the thin-film microextraction (TFME) method. On cellulose
paper, ZnS/MoS2
was grown using a simple, easy, and inexpensive
hydrothermal method. The digoxin was quantified after TFME using highperformance liquid chromatography-UV detection (HPLC-UV). The effect
of effective parameters such as extraction time, extraction temperature,
agitation speed, and sample ionic strength was investigated, and the best
conditions were selected. Under ideal conditions, a calibration curve with
good linearity (R2
=0.987) and a low limit of detection (LOD) in the range
of 0.01–100 ng mL-1 was obtained. The detection limits were 0.03 ng mL-1.
For the digoxin, the relative standard deviations (RSDs) were 5.3%. The
method was successfully applied to the study of urine and plasma. Relative
recoveries were found to range between 96% and102 %. The proposed
method provided a straightforward, efficient, and environmentally
friendly way for determining digoxin in real-world samples.
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