عنوان مجله
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Trends in Phytochemical Research
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چکیده
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investigated the effects of a hydro-ethanolic extract of Echinophora platyloba L. (Apiaceae) on
the rewarding effects of morphine. The rewarding effects of morphine and the plant extract
were evaluated using a conditioned place preference (CPP) paradigm in mice. Additionally,
the effects of administering the plant extract on the expression and acquisition of morphine
CPP were investigated. Finally, the role of opioid receptors in the CPP of the plant extract was
determined. Both morphine and the extract induced a significant CPP. Furthermore, naloxone
could inhibit the CPP of the plant extract. The plant extract had no effect on the expression
of morphine CPP, but it significantly inhibited the acquisition of morphine CPP. Consequently,
the extract of E. platyloba L. has rewarding effects, which may be mediated through opioid
receptors. The extract can also inhibit the acquisition of morphine CPP.
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