عنوان A novel multicomponent reaction between amino acids, aromatic aldehydes and p-toluenesulfonylmethyl isocyanide: an ef fi cient and green one-pot synthesis using nanosilica عنوان مجله Green Chemistry Letters and Reviews نوع پژوهش مقاله چاپ شده کلیدواژهها Ugi reaction; tosyl acyloxy amino carboxamide derivatives; amino acid; aromatic aldehydes; toluenesulfonylmethyl isocyanide; silica nanoparticles چکیده The novel diastereomeric sulfonylamide derivatives 4a – h were synthesized by multi-component reactions between (L)- α -amino acids, 1, aromatic aldehydes, 2 and p-toluenesulfonylmethyl isocyanide, 3 in water/methanol using nanosilica as a catalyst. The one-pot green reactions were carried out at room temperature with a quantitative yield in water/methanol. The yield of the reactions and products was determined and discussed. The reusablity of the catalyst is discussed. پژوهشگران لادناجلاسی (نفر اول)، اسماعیلوصالی (نفر دوم)، زهراجعفری (نفر سوم)، مهدیاسرافیلی دیزجی (نفر چهارم)