مشخصات پژوهش

عنوان	Adaptive Response of Blood Lymphocytes of Inhabitants Residing in High Background Radiation Areas of Ramsar- Micronuclei, Apoptosis and Comet Assays
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	High Natural Radiation Areas in Ramsar, Micronuclei, Apoptosis, Comet assay, Radio-adaptive Response
چکیده	The hot springs in certain areas of Ramsar contain 226Ra and 222Rn. The effects of natural radiation on the inhabitants of these areas and the inhabitant's radiosensitivity or adaptive responses were studied. One group of volunteers from areas with high natural background radiation and another group from areas with normal background radiation were chosen as the case and control group respectively. The frequency of micronuclei, apoptosis, and DNA damage in peripheral blood mononuclear cells were measured following γ irradiation (4 Gy). The incidence of micronuclei in the case group was significantly lower than that in the control group while their frequency of apoptosis was higher (P < 0.05). However, the rates of induced DNA damage and repair were significantly higher in the case group (P < 0.05). Smaller number of micronuclei and higher levels of apoptosis in the case group could be the result of higher resistance to radiation stress and a more rigorous checkpoint at cell division. However, regarding the alkaline labile sites, the individuals in the case group are more sensitive and susceptible to DNA damage. The results of micronuclei, apoptosis and repair studies suggest that an adaptive response might be induced in people residing in areas with high background radiation.
پژوهشگران	شهلا محمدی (نفر اول)، مهناز تقوی دهاقانی (نفر دوم)، محمد رضا قرائتی (نفر سوم)، رضا معصومی جهاندیزی (نفر چهارم)، مهدی غیاثی نژاد (نفر پنجم)