مشخصات پژوهش

عنوان	pH-responsive magnetic biocompatible chitosan-based nanocomposite carrier for ciprofloxacin release
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Magnetic montmorillonite Chitosan Ciprofloxacin release pH-dependent
چکیده	The pH-sensitive and magnetic-triggered release ensures the effective delivery of drugs. Chitosan carries amine pendants that encourage the fabrication of pH-responsive carriers. Montmorillonite (MMt), an attractive nano-clay in drug delivery possessing high encapsulation properties, was magnetized through the co-precipitation of Fe3+/Fe2+ ions. The study aimed to integrate the magnetic montmorillonite (mMMt) into the chitosan matrix and crosslinked by citric acid (CA) to achieve the nanocomposite carrier with double-responsive features for effective drug delivery. The release evaluation revealed that coating the mMMt with CA-crosslinked chitosan prevented the burst release of Ciprofluxcacin (Cip). The nanocomposite showed a high sustained release, and the release rate in the neutral environment (pH 7.4) was remarkably higher than in acidic media (pH 5.8). The new nanocomposite carrier showed high encapsulation efficiency to Cip (about 98 %). The study was developed by investigating external magnetic effects on the release rate, which lead to an increase in the release rate. The kinetics studies confirmed the diffusion mechanism for Cip release in all experimental media. The Cip-loaded nanocomposite carriers showed antibacterial activity against E. coli and S. aureus.
پژوهشگران	شهرزاد جوانشیر (نفر ششم به بعد)، حسام جعفری (نفر ششم به بعد)، پریسا لبیب (نفر پنجم)، باقر کاظمی (نفر چهارم)، پریسا فتحی رضایی (نفر سوم)، غلامرضا مهدوی نیا (نفر دوم)، پریناز جباری (نفر اول)