مشخصات پژوهش

عنوان	Dual-drug (Curcumin/Ciprofloxacin) loading and release from chitosan-based hydrogels embedded with magnetic Montmorillonite/Hyaluronic acid for enhancing wound healing
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Magnetic montmorillonite, Chitosan, Hyaluronic acid, Drug release, Wound healing
چکیده	Montmorillonite (MMt) is extensively applied as an efcient drug-carrier in designing drug delivery systems (DDS) due to its high specifc surface area to load drugs. Modifcation of MMt via iron (Fe) blending can thus be a desirable method to improve its biocompatibility. Herein, magnetic nano-carriers involving the magnetic MMt (mMMt) core surrounded by chitosan (Chito) as a biopolymer and hyaluronic acid (HA) were prepared. To coat the mMMt fabricated through the coprecipitation of the Fe3+/Fe2+ ions in the presence of MMt, the acquired mMMt as the core was then treated with the Chito/HA solution to induce the cross-linked Chito/HA as the shell (namely, the Chito/HA-mMMt). The transmission electron microscopy (TEM) results accordingly revealed the existence of the mMMt inside the Chito/ HA solution. Curcumin (CUR) and ciprofoxacin (CIP) were further employed as two model drugs. The CUR and CIP release from the Chito/HA-mMMt subsequently occurred in a sustained manner and pH-dependently. Additionally, an upsurge in the CUR and CIP release by applying an external magnetic feld was observed. Thus, the prepared Chito/HA-mMMt hydrogels promise an outstanding potential performance in terms of expanding novel pH-dependent DDS with a sustained release behavior. The scratch assay of the given hydrogels also confrms their applications for wound healing.
پژوهشگران	زهرا سیار (نفر اول)، غلامرضا مهدوی نیا (نفر دوم)، علیرضا ختایی (نفر سوم)