مشخصات پژوهش

عنوان	A Luminescent Amine-Functionalized Metal–Organic Framework Conjugated with Folic Acid as a Targeted Biocompatible pH-Responsive Nanocarrier for Apoptosis Induction in Breast Cancer Cells
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Cancer,Cells,Drug release,Nutrition,Organic compounds
چکیده	Folic acid amine-functionalized metal–organic framework (FOLA@NH2-Eu:TMU-62) with luminescent properties loaded with 5-fluorouracil (5-Fu), as an anticancer medication, was used to construct a new cancer targeted drug delivery system in the present study. The 5-Fu release from this targeted carrier along with MTT assay and trypan blue dye exclusion test results also exhibited pH-controlled characteristics of the given carrier in acidic environments, which is very suitable for targeting solid tumors. Then, the inhibitory action of 5-Fu-loaded FOLA@NH2-Eu:TMU-62 for Michigan Cancer Foundation-7 (MCF7) cell migration was explored according to scratch wound healing assays. Based on the results, the FOLA@NH2-Eu:TMU-62 carrier was not toxic for MCF-10A normal cells, but it was significantly toxic for MCF-7 breast cancer ones, revealing that the FOLA@NH2-Eu:TMU-62 carrier could be utilized in accurate cancer treatments through apoptotic pathways with higher reactive oxygen species compared with 5-Fu alone. This cancer-targeted design of FOLA@NH2-Eu:TMU-62 could thus pave the way for synergistic effects of targeting as well as organized release capabilities.
پژوهشگران	رضا اباذری (نفر اول)، فرنگیس عطائی (نفر دوم)، علی مرسلی (نفر سوم)، الکساندرا اسلاوین (نفر چهارم)، کامرون کارپنتر-وارن (نفر پنجم)