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عنوان
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A novel multicomponent reaction between amino acids, aromatic aldehydes and p-toluenesulfonylmethyl isocyanide: an ef fi cient and green one-pot synthesis using nanosilica
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نوع پژوهش
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مقاله چاپشده در مجلات علمی
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کلیدواژهها
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Ugi reaction; tosyl acyloxy amino carboxamide derivatives; amino acid; aromatic aldehydes; toluenesulfonylmethyl isocyanide; silica nanoparticles
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چکیده
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The novel diastereomeric sulfonylamide derivatives 4a – h were synthesized by multi-component reactions between (L)- α -amino acids, 1, aromatic aldehydes, 2 and p-toluenesulfonylmethyl isocyanide, 3 in water/methanol using nanosilica as a catalyst. The one-pot green reactions were carried out at room temperature with a quantitative yield in water/methanol. The yield of the reactions and products was determined and discussed. The reusablity of the catalyst is discussed.
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پژوهشگران
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مهدی اسرافیلی دیزجی (نفر چهارم)، زهرا جعفری (نفر سوم)، اسماعیل وصالی (نفر دوم)، لادن اجلاسی (نفر اول)
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